Association Between SLCO1B1 Gene T521C Polymorphism and Statin-Related Myopathy Risk A Meta-Analysis of Case-Control Studies

摘要

Statin-related myopathy is an important adverse effect of statin which is classically unpredictable. The evidence of association between solute carrier organic anion transporter 1B1 (SLCO1B1) gene T521C polymorphism and statin-related myopathy risk remained controversial. This study aimed to investigate this genetic association.Databases of PubMed, EMBASE, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Chinese Scientific Journals Database, and Wanfang Data were searched till June 17, 2015. Case-control studies investigating the association between SLCO1B1 gene T521C polymorphism and statin-related myopathy risk were included. The Newcastle-Ottawa Scale (NOS) was used for assessing the quality of included studies. Data were pooled by odds ratios (ORs) and their 95% confidence intervals (CIs).Nine studies with 1360 cases and 3082 controls were included. Cases of statin-related myopathy were found to be significantly associated with the variant C allele (TC+CC vs TT: OR=2.09, 95% CI=1.27-3.43, P=0.003;C vs T: OR=2.10, 95% CI=1.43-3.09, P<0.001), especially when statin-related myopathy was defined as an elevation of creatine kinase (CK) >10 times the upper limit of normal (ULN) or rhabdomyolysis (TC+CC vs TT: OR=3.83, 95% CI=1.41-10.39, P=0.008;C vs T: OR=2.94, 95% CI=1.47-5.89, P=0.002). When stratified by statin type, the association was significant in individuals receiving simvastatin (TC+CC vs TT: OR=3.09, 95% CI=1.64-5.85, P=0.001;C vs T: OR=3.00, 95% CI=1.38-6.49, P=0.005), but not in those receiving atorvastatin (TC+CC vs TT: OR=1.31, 95% CI=0.74-2.30, P=0.35;C vs T: OR=1.33, 95% CI=0.57-3.12, P=0.52).The available evidence suggests that SLCO1B1 gene T521C polymorphism is associated with an increased risk of statin-related myopathy, especially in individuals receiving simvastatin. Thus, a genetic test before initiation of statins may be meaningful for personalizing the treatment.