ASSOCIATION OF ITGA1 GENE POLYMORPHISMS WITH BONE MINERAL DENSITY AND FRACTURE RISK

摘要

ITGA1(integrin A1) gene polymorphisms associated with bone mineral density(BMD) and fracture risk are provided to predict susceptibility to osteoporosis or fracture risk of a subject, so that the gene polymorphisms are useful as marker of osteoporosis genetic predisposition. An ITGA1 gene polymorphism marker for predicting susceptibility to osteoporosis is +73187CT(exon 3), +76969TG(intron 5), or their haplotype BL1_ht1, wherein +73187th base is C and +76969th base is T or BL1_ht2, wherein +73187th base is T and +76969th base is G which is associated with BMD of femoral neck and femoral shaft; +159174AC(intron 28) or its BL3_ht1 , wherein +159174th base is C, +164104th base is C and +165697th base is T which is associated with fracture risk; or BL2-ht3, wherein +109100th base is T, +110140th base is G, and +130991st base is C which is associated with BMD of Ward's triangle. A method for predicting susceptibility to osteoporosis comprises the steps of: (1) collecting a DNA sample from a subject; (2) detecting the ITGA1 gene polymorphism marker from the DNA sample; and (3) identifying the detected ITGA1 gene polymorphism.