ASSOCIATION OF PLXNA2 POLYMORPHISMS WITH VERTEBRAL FRACTURE RISK AND BONE MINERAL DENSITY

摘要

PLXNA2 (plexin A2) gene pleiomorphism, itself and vertebral fracture risk and bone density (BMD), it is arranged to predict the genetic predisposition of osteoporosis and the sensibility of the osteoporosis to a theme, so that gene pleiomorphism is used as the useful mark for the associated fracture of osteoporosis and there. A PLXNA2 gene pleiomorphisms of a for predict be to the sensibility of osteoporosis+14G ,+183429C T or haplocype Block1-ht2, wherein it is the danger that G associated with vertebral fracture risks it that+14th bases, which are G and+799th bases,; Or it is associated with the BMD of entire femur, rotor, femoral shaft and ward's triangle by+799G a ,+135391G a or+190531G C. For predicting the priming paint for not containing SEQ ID to the sleeve piece of the sensibility of osteoporosis: 1 pair of SEQ ID not: 70 for not screening the series jump of PLXNA2 gene pleiomorphisms and the priming paint and probe of SEQ ID: 71 pairs of SEQ IDs not: 114 be genotyping.