Mild Caloric Restriction Decreases Insulin Requirements in Patients With Type 2 Diabetes and Severe Insulin Resistance

摘要

Type 2 diabetes (T2D) affects approximate to 10% of the US population, a subset of whom have severe insulin resistance (SIR) (>200units/d). Treatment of these patients with high-dose insulin presents logistical and compliance challenges. We hypothesized that mild caloric restriction would reduce insulin requirements in patients with T2D and SIR.This was a retrospective study at the National Institutes of Health Clinical Center. Inclusion criteria were as follows: T2D, and insulin dose >200units/d or >2units/kg/d. The intervention consisted of mild caloric restriction during a 3 to 6-day hospitalization. The major outcomes were change in insulin dose and blood glucose from admission to discharge.Ten patients met inclusion criteria. Baseline glycated hemoglobin A(1c) was 10.01.6% and body mass index 38.8 +/- 9.0kg/m(2). Food intake was restricted from 2210 +/- 371kcal/d preadmission to 1810 +/- 202 during the hospital stay (16.5% reduction). Insulin dose decreased from 486 +/- 291units/d preadmission to 223 +/- 127 at discharge (44% reduction, P=0.0025). Blood sugars decreased nonsignificantly in the fasting state (from 184 +/- 85 to 141 +/- 42, P=0.20), before lunch (239 +/- 68 to 180 +/- 76, P=0.057), and at bedtime (212 +/- 95 to 176 +/- 48, P=0.19), and significantly decreased before dinner (222 +/- 92 to 162 +/- 70, P=0.016).Mild caloric restriction, an accessible and affordable intervention, substantially reduced insulin doses in patients with T2D and SIR. Further studies are needed to determine if the intervention and results are sustainable outside of a hospital setting.