Gender differences in treatment of cardiovascular disease: a task force on gender of the ESC proposal on gender specific studies in cardiovascular pharmacology.

摘要

In the past decades attention has been focused on gender differences in the access to health care resources and therapies but little emphasis has been put on the understanding of the basic mechanisms of gender differences and different action of cardiovascular drugs. Evidence has been cumulating suggesting that plas-matic and circulating cells may be influenced by cardiovascular risk factors and that these changes may affect vascular functions and progression of atherosclerosis [1-3]. Sex hormones improve endothelial repair after vascular injury but the gender differences in the functionality of plasmatic and circulating cells are not well understood. Malorni et al. discuss the basic mechanisms related to gender differences in circulating cells shape, function and survival and their relation to the progression of cardiovascular disease.