Does Fat Suppression via Chemically Selective Saturation Affect R2*-MRI for Transfusional Iron Overload Assessment? A Clinical Evaluation at 1.5T and 3T

摘要

Purpose: Fat suppression (FS) via chemically selective saturation (CHESS) eliminates fat-water oscillations in multiecho gradient echo (mGRE) R2*-MRI. However, for increasing R2* values as seen with increasing liver iron content (LIC), the water signal spectrally overlaps with the CHESS band, which may alter R2*. We investigated the effect of CHESS on R2* and developed a heuristic correction for the observed CHESS-induced R2* changes.