Multiresponsive Properties of Triple-Shell Architectures with Poly(N, N -diethylaminoethyl methacrylate), Poly(N -vinylcaprolactam), and Poly (N, N -dimethylaminoethyl methacrylate) as Building Blocks

摘要

Triple-shell architectures, consisting of poly[(N,N -diethylaminoethyl methacrylate)- block -(N - vinylcaprolactam)- block -(N,N -dimethylaminoethyl methacrylate)] triblock copolymers, are obtained by sequential reversible addition–fragmentation chain transfer polymerizations, using a terminal-modifi ed hyperbranched poly(β -cyclodextrin) core as a macro chain transfer agent. UV-vis spectroscopy results indicate that the triple-shell architectures possess one pH response at pH 12.5 in aqueous solution at room temperature, followed by double-temperatureresponsiveness between 33 ° C and 36 ° C. The special multiresponsive properties are further confi rmed by investigating the controlled release behavior of the resulting polymers using metronidazole as a model drug.