Synthesis of Thermo-Sensitive Polyelectrolyte Complex Nanoparticles from CS-g-PNIPAM and SA-g-PNIPAM for Controlled Drug Release

摘要

In this paper, thermo-sensitive polyelectrolyte complex nanoparticles assembled from ohitosm-sraft-poly(N-isopr0pykcrylarmde)(CS-g-PNIPAM)and sodium alginate-graft-poli(N-isopropylacylamide)(SA-g-PIPAM) were prepared for entrapment and release of 5-fluorouracil(5-FU). The morphology and size of the nanoparticles were observed by transmission electron microscopy (TEM) and dynamic light scattering (DLS) The polyelectrolyte com plex nanoparticles showed a narrow size distribution. The hydrogen bonding interactions between nanoparticles and 5-FU, which was determined by fourier-transformed infrared spectroscopy (FTIR), increased drug loading Glutar-aldehyde, as a cross-linking agent, reinforced the nanoparticle structure and decreased the burst drug release When changing temperature, pH, or ionic strength, a sustained and controlled drug release was observed The novel com plex nanoparticles with environmentally sensitive properties are expected to be useful in the field of intelligent drug delivery system.