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SYNTHESIS OF PRODRUGS OF IBUPROFEN AND NANOPARTICLES PREPARATION USING POLY (L-LACTIDE) FOR CONTROLLED DRUG RELEASE
SYNTHESIS OF PRODRUGS OF IBUPROFEN AND NANOPARTICLES PREPARATION USING POLY (L-LACTIDE) FOR CONTROLLED DRUG RELEASE
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机译:聚(L-丙交酯)用于药物释放的布洛芬前驱体和纳米颗粒的合成
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摘要
The present invention discloses a process for the synthesis of alkyl ester pro drugs of Ibuprofen of formula (I) and its encapsulation with polymeric nanoparticles for controlled drug release. More particularly, the present invention discloses a process for the synthesis of alkyl ester prodrugs of Ibuprofen of formula (I) from respective alcohols with increased pharmacological activity, low ulcerogenicity and good chemical stability. Further, the present invention discloses the study of said drug in vitro and in vivo controlled release pattern. Formula (I)
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