CELLULOSE NANOPARTICLES BASED ESTER PRODRUGS FOR POTENTIAL COLON-SPECIFIC DRUG DELIVERY. SYNTHESIS PHYSICOCHEMICAL CHARACTERIZATION AND DRUG RELEASE STUDIES (PPT)

摘要

Ester prodrug either of xylan based or of cellulose based has been successfully synthesized as confirmed by FT-IR and 1H/13C-NMR Spectroscopy. X-ray diffraction analysis showed that ester prodrugs have broader peak with less crystalline content. The decrease in crystallinity of prodrug might be facilitating the degradation of cellulose/xylan by produced enzymes in the colon. The crystallinity of cellulose based ester prodrugs of molar ratio 1:1 and 1:2 have almost constant, on the other hand ester prodrug of molar ratio of 1:3 has some what less crystallinity might be due to conjugation at C-6 carbon atom of cellulose. Smaller particle size of both cellulose/xylan based ester prodrugs provide large surface area for facilitating the enzyme action easily.