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Nanoparticles comprising polyelectrolyte complex of polycation, polyanion and biologically active agent, especially useful for controlled drug release on oral administration
Nanoparticles comprising polyelectrolyte complex of polycation, polyanion and biologically active agent, especially useful for controlled drug release on oral administration
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机译:包含聚阳离子,聚阴离子和生物活性剂的聚电解质复合物的纳米颗粒,特别适用于口服给药时的控释
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摘要
Nanoparticles comprising a biocompatible, biodegradable polyelectrolyte complex consisting of a polycation, a polyanion and a biologically active agent are produced by crosslinking the polyelectrolyte complex during or after its formation. An Independent claim is also included for the production of the nanoparticles by combining the active agent in bound or unbound form with an aqueous polycation solution and an aqueous polyanion solution, if necessary converting the resulting polyelectrolyte complex into nanoparticulate form, and treating the nanoparticulate complex with a crosslinking agent.
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