NANOPARTICLES OF ANTIOXIDANT ENZYME SUPEROXIDE DISMUTASE IN FORM OF POLYELECTROLYTE COMPLEX OF ENZYME-POLYCATION-POLYANION COMPOUND AND METHOD FOR PRODUCTION THEREOF

摘要

FIELD: chemistry.;SUBSTANCE: enzyme is coated with an internal envelope of a polycation and an external envelope of a polyanion, where the polycation used is protamine or polyarginine, the polyanion used is a block-copolymer of poly(glutamic acid) and polyethylene glycol, wherein the nanoparticle has a hydrodynamic diameter in the range of 40-70 nm. The invention also relates to a dispersion which contains nanoparticles of the antioxidant enzyme superoxide dismutase for medical use in the form of polyelectrolyte complexes of the type enzyme/polycation/polyanion, and a method of producing said dispersion.;EFFECT: high stability of the enzyme in a foreign medium with preservation of the activity of the enzyme.;9 cl, 1 dwg, 1 tbl