'Smart' Microspheres for Self-Renewal of Embryonic Stem Cells

摘要

Microspheres for growth factor delivery have been developed, but the growth factors were simply adsorbed to the microsphere surfaces and could not be released precisely by environmental stimuli. The control of pore size and porosity is very important because these parameters determine cell migration, diffusion, and the transport of nutrients. Conventional hydrogels had limited permeability with small pores and thus, many methods for pore formation have been developed. Elastin like polypeptide (ELP) microspheres as 3D porous scaffolds can enhance the attachment of cells and control the release rate of biomolecules through porous structure control by temperature stimuli.