Detection of illicit drugs in oral fluid from drivers as biomarker for drugs in blood

摘要

Aim: To assess whether analysis of oral fluid can be used to identify individual drivers with drug concentrations in blood above 25 ng/mL for amphetamine and methamphetamine, 10 ng/mL for cocaine and 1.0 ng/mL for tetrahydrocannabinol (THC), which are the cut-off concentrations used in the European DRUID Project, by calculating the diagnostic accuracies when using the analytical cut-off concentrations in oral fluid as well as for the optimal cut-off concentrations.