Selective synthesis of trisubstituted (trifluoromethyl) alkenes via ligand-free Cu-catalyzed syn hydroarylation, hydroalkenylation and hydroallylation of (trifluoromethyl) alkynes

摘要

In the presence of catalytic amounts of Cu(OAc)(2), the hydroarylation of (trifluoromethyl) alkynes with arylboronic acids proceeded in MeOH at 28 degrees C to afford diverse beta-(trifluoromethyl) styrenes. Moreover, the hydroalkenylation and hydroallylation of a (trifluoromethyl) alkyne using styryl- and allylboronates afforded trifluoromethylated 1,3- and 1,4-dienes.