Determination of optimal vitamin D-3 dosing regimens in HIV-infected paediatric patients using a population pharmacokinetic approach

摘要

AimsTo investigate 25-hydroxycholecalciferol [25(OH)D] population pharmacokinetics in children and adolescents, to establish factors that influence 25(OH)D pharmacokinetics and to assess different vitamin D-3 dosing schemes to reach sufficient 25(OH)D concentrations (>30ngml(-1)).