Dynamic modelling for estimating the cost-effectiveness of a Chlamydia trachomatis screening program

摘要

Objective: To estimate the cost-effectiveness of a systematic Chlamydia trachomatis (CT) screening program including partner treatment for the Netherlands using a dynamic approach.Methods: Data on infection prevalence, participation rates and sexual behaviour were obtained from a large pilot study conducted in the Netherlands. We developed a dynamic SIS model, that is widely used in exploring the transmission dynamics of other infectious diseases, to estimate the impact of the screening program on the incidence and prevalence of CT in the population. Subsequently,a progression-of-disease tree was used to calculate the complications averted by the screening program. Cost-effectiveness is expressed as the net costs per major outcome averted (MOA). We compared doing nothing both with a one-off screening program and with screening on various time intervals.