Driving High Sensitivity in Biomolecular MS: Improving This Key Parameter Enables Novel Applications and Powers Additional Techniques

摘要

Mass spectrometry has become a key tool for the analysis of biomolecules in applications that range from discovery of biomark-ers to the analysis of drug metabolites. While many of the analytical benchmarks of the mass spectrometer—limit of quantitation or LOQ, signal-to-noise or S/N, dynamic range, mass resolution—are important for these applications, the absolute sensitivity is a key factor that drives these characteristics.