4-[(N-Imidazol-2-ylmethyl)anilino]pyranopyridine Analogs as Novel Anti-Angiogenic Agents

摘要

We attempted to replace a benzopyran ring of 4-[(N-imidazol-2-ylmethyl)-4-chloroanilino]benzopyran,previously discovered as anti-angiogenic agent with antitumor activity,with pyranopyridines.The [3,2-c]-,[3,2-b]-,[2,3-c]-,and [2,3-b]-pyranopyridines with N-(imidazol-2-ylmethyl)aniline moiety at the 4-position,were synthesized respectively,and evaluated for primary anti-angiogenic properties through primary cultured HUVEC tube formation assay.From this study,we found that the pyranopyridine ring,especially [3,2-b]-and [2,3-c]-isomer,can replace the benzopyran ring of the compound 1 and can be optimized through the introduction of substituents both on the pyranopyridine ring and the aniline moiety for the identification of a novel anti-angiogenic agent.