Identification of a novel antiangiogenic agent; 4-(N-imidazol-2-ylmethyl)amino benzopyran analogues.

Kim N; Lee S; Yi KY; Yoo SE; Kim G; Lee CO; Park SH; Lee BH

首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >Identification of a novel antiangiogenic agent; 4-(N-imidazol-2-ylmethyl)amino benzopyran analogues.

【24h】

Identification of a novel antiangiogenic agent; 4-(N-imidazol-2-ylmethyl)amino benzopyran analogues.

机译：鉴定新型抗血管生成剂; 4-（N-咪唑-2-基甲基）氨基苯并吡喃类似物。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A series of 4-(N-imidazol-2-ylmethyl)aminobenzopyran analogues, originally designed as K(ATP) openers for ischemic diseases, showed antiangiogenic properties through the inhibition of HUVEC tube formation. Especially one of p-Cl substituted analogues (4c) completely inhibited HUVEC tube formation at 10 microM. The compound 4c significantly inhibited tumor growth by 52% on A549 (human non small cell lung carcinoma) in nude mice xenografts without any significant side effects.

机译：最初设计为缺血性疾病的K（ATP）开启剂的一系列4-（N-咪唑-2-基甲基）氨基苯并吡喃类似物通过抑制HUVEC管的形成显示出抗血管生成的特性。尤其是p-Cl取代的类似物（4c）之一在10 microM时完全抑制了HUVEC管的形成。化合物4c在裸鼠异种移植物中对A549（人非小细胞肺癌）显着抑制了肿瘤生长52％，而没有任何明显的副作用。

著录项

来源
《Bioorganic and Medicinal Chemistry Letters》 |2003年第10期|共3页
作者
Kim N; Lee S; Yi KY; Yoo SE; Kim G; Lee CO; Park SH; Lee BH;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
novel; 4c; Identification (Psychology); Benzopyrans; 认同(心理学); 苯吡喃类;

机译：novel;4c;Identification (Psychology);Benzopyrans;认同(心理学);苯吡喃类;

相似文献

外文文献
中文文献
专利

1. Identification of a novel antiangiogenic agent; 4-(N-imidazol-2-ylmethyl)amino benzopyran analogues. [J] . Kim N, Lee S, Yi KY, Bioorganic and Medicinal Chemistry Letters . 2003,第10期

机译：鉴定新型抗血管生成剂; 4-（N-咪唑-2-基甲基）氨基苯并吡喃类似物。
2. Small Molecule Mitochondrial F_1F_0 ATPase Hydrolase Inhibitors as Cardioprotective Agents. Identification of 4-(N-Arylimidazole)-Substituted Benzopyran Derivatives as Selective Hydrolase Inhibitors [J] . Karnail S. Atwal, Paulina Wang, W. Lynn Rogers, Journal of Medicinal Chemistry . 2004,第5期

机译：小分子线粒体F_1F_0 ATPase水解酶抑制剂作为心脏保护剂。鉴定4-（N-Arylimidazole）取代的苯并吡喃衍生物作为选择性水解酶抑制剂
3. Further structure-activity relationship studies on 4-((((3 S,6 S)-6-benzhydryltetrahydro-2 H -pyran-3-yl)amino)methyl)phenol: Identification of compounds with triple uptake inhibitory activity as potential antidepressant agents [J] . Gopishetty B., Hazeldine S., Santra S., Journal of Medicinal Chemistry . 2011,第8期

机译：4-（（（（（3 S，6 S）-6-benzhydryltetrahydro-2 H -pyran-3-yl）amino）methyl）phenol的进一步结构活性关系研究：鉴定具有三重吸收抑制活性的化合物作为潜在的抗抑郁药代理商
4. Synthesis of 4-(4-alkylphenyl)-4'-amino-α-methyl-stilbene,4-(4-alkylphenyl)-4'-isothiocyanato-α-methylstilbene, and 4-(4-alkylphenyl)-4'-cyano-α-methylstilbene liquid crystals [C] . C.S. Hsu, C.Y. Chang International Display Manufacturing Conference FPD Expo(IDMC'03) . 2003

机译：4-（4-烷基苯基）-4'-氨基-α-甲基-，4-（4-烷基苯基）-4'-异硫氰酸根合-α-甲基sti和4-（4-烷基苯基）-4'-的合成氰基-α-甲基sti液晶
5. POTENTIAL ANTITUMOR AGENTS AND PREPARATION OF THIENO(3,2-C)(1)BENZOPYRAN-4-ONES [D] . MINATELLI, JOHN ADRIAN. 1974

机译：噻吩（3,2-C）（1）苯并吡喃-4-酮的潜在抗抗原剂和制备
6. Further structure-activity relationship studies on 4-((((3S6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: Identification of compounds with triple uptake inhibitory activity as potential antidepressant agents [O] . Bhaskar Gopishetty, Stuart Hazeldine, Soumava Santra, -1

机译：4进一步的结构 - 活性关系的研究 - （（（（3s6s）-6- benzhydryltetrahydro -2H-吡喃-3-基）氨基）甲基）苯酚：作为潜在抗抑郁药具有三重摄取抑制活性的化合物的鉴定
7. 4-(N-Imidazol-2-ylmethyl)anilinopyranopyridine Analogs as Novel Anti-Angiogenic Agents [O] . 2005

机译：4 - （N-咪唑-2-基甲基）苯胺吡啶吡喃吡啶类似物作为新型抗血管生成剂

Identification of a novel antiangiogenic agent; 4-(N-imidazol-2-ylmethyl)amino benzopyran analogues.

摘要

著录项

相似文献

相关主题

期刊订阅