Synthesis of Methyl(E)-2-Cyanomethylcinnamates Derived from Baylis-Hillman Acetates and Conversion into Several 4-Hydroxy-2-naphthoie Acids and Benzylidenesuccinimides

摘要

The Baylis-Hillman(BH)reaction has been developed enormously over the past few years due to its wide applicability towards formation of multifunctional derivatives,heterocycles3 and natural products.Aliphatic nitriles are potentially useful building block in organic synthesis due to the electron-withdrawing nature associated with the cyano group and the conversion of the cyano group into other functionalities.Much attention has recently been focussed on the S_N2' nucleophilic substitution of the Baylis-Hillman acetates.Among them only limited approaches to the cyanation of BH adducts are known in the literature.