Synthesis of methyl (E)-2-nitromethylcinnamates derived from Baylis-Hillman acetates and conversion into several coumarin derivatives

摘要

Fast and easy access to methyl (E)-2-nitromethylcinnamates, from the corresponding Baylis-Hillman acetates with NaNO2 in DMF is described. Several ortho-chloro-2-nitromethylcinnamates undergo intramolecular aromatic substitution reaction followed by rearrangement to yield coumarin derivatives.