Efficient Copper Bromide Catalyzed Chemoselective Thioacetalization of Carbonyl Compounds:Selectivity and Scope

摘要

Protections of carbonyl groups as thioacetals are quite often a necessary requirement in the synthesis of multifunctional organic molecules.Thioacetals are quite stable toward a wide variety of reagents and are useful in organic synthesis as acyl carbanion equivalents in C-C bond-forming reactions.Further,the use of thioacetals as blocking groups has allowed a new strategy for the electrophilic substitution on the carbonyl compound.