NOVEL 1-2-(4-HYDROXY-3- METHOXYPHENY) ETHENY L-4{3-4NITROPHENYI)METHYLIDENEAMINO -5-OXO-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBONYL}PYRIDINE-1-IUM BROMIDE AND 1-2-(4-HYDROXY-3-METHOXYPHENYL)ETHENYL-4-{N'-(4-PHENOXYPHENYL) METHYLIDENE HYDRAZINECARBONYL} PYRIDINE-1-IUM BROMIDE COMPOUNDS FOR ANTI-TUBERCULOSIS ACTIVITY

摘要

From the invention revealed that, a novel attempt was made to synthesize two novel compounds based on insilico studies and hybridized with more potent antibacterial Heptoprotective (Eugenol) and bacteriostatic fragments to the pyridine-4-carbohydrazide which leads to effective against resistant strains of mycobacterium tuberculosis with more potent and devoid of toxicities. Particularly with reference to compound 10 and compound 3 showed promising results to overcome those entire problems shooting areas in tuberculosis Chemical Structure C-3