Synthesis, Cytotoxicity and Topoisomerase II Inhibition Study of New Thioxanthone Analogues

摘要

Xanthone (1) compounds found as secondary metabolites from higher plants and microorganisms have wide biological profiles including anti-hypertensive, anti-oxidative, antithrombotic, and anti-cancer activity, based on their diverse structures. The interesting structural scaffold and biological efficacy of xanthones enforced many scientists to synthesize these compounds for the development of prospective new drug candidates. Among these xanthones, oxygenated xanthones synthesized or isolated from natural sources revealed effective inhibitory activity against several cancer cell lines. Especially, 2',3'-epoxypropoxy substituted xanthones have efficiently prohibited growth of cancer cells and xanthone (2) possessing two 2',3'-epoxypropoxy groups at 3 and 5 position showed most active anticancer activity in the series prepared.