Synthesis of Quinolines via Pd/C-Catalyzed Cyclization of 2-Aminobenzyl Alcohol with Ketones

摘要

It is known that quinoline plays an important role as a basic skeleton for the design of many pharmacologically active compounds such as antiasthmatic,anti-inflammatory and antimalarial.1 During the course of our studies directed towards C-N bond activation,we have reported the ruthenium-catalyzed synthesis of quinolines via an alkyl or alkanol group transfer from alkylamines or alkanolamines to N-atom of anilines (amine exchange reaction),followed by cascade isomerization and cyclization of 3-(2-aminophenyl)-l-arylprop-2-yn-1-ols.