Orally Applied Novel Organogermanium Improves Skin Inflammation in NC/Nga Mice with Atopic Dermatitis

摘要

It has been reported that compounds containing germanium (Ge) have a broad range of biological activities. In general, inorganic forms of germanium are severely toxic to certain organs and tissues, whereas organic forms of germanium compounds appear to be less toxic for mammals. Therefore, many organogermanium compounds have been synthesized and investigated for their pharmacological activities. However, in spite of its beneficial effects, long-term ingestion or a high dose of organic Ge-132 is known to cause toxic effects.4 Ge-132 is a water-insoluble polymer which is chemically synthesized from GeO2 and an organic acid. During purification, Ge-132 can easily be contaminated by significant amounts of toxic inorganogermanium or other hazardous impurities.