Antipsychotic medications do not differ substantially in ability to reduce violent behaviour in people with schizophrenia.

摘要

Question: Do antipsychotic medications differ in the ability to reduce violent behaviour in people with schizophrenia? Patients: 1493 adults with schizophrenia (DSM-IV), aged 18-65 years. Detailed inclusion and exclusion criteria are not reported in this article.Setting: The NIMH Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project; 57 US sites (academic and community); January 2001-December 2004. Intervention: Olanzapine (7.5 mg capsule), quetiapine (200 mg capsule), risperidone (1.5 mg), perphenazine (8 mg capsule) or ziprasidone (40 mg capsule). Doses were altered according to clinical judgement, with up to 4 capsules given daily. Outcomes: Primary outcome: change in violent behaviour from baseline to 6 months (MacArthur Community Violence Interview-a combined measure of minor (eg, assault without injury) and serious (eg, assault with a weapon) violent behaviours). Information was collected from both the participant and family members.