COMPOSITION CONTAINING ANTIPSYCHOTIC MEDICATION AND GLUCOCORTICOID RECEPTOR ANTAGONIST FOR WEIGHT REDUCTION ASSOCIATED WITH ANTIPSYCHOTIC MEDICATIONS

摘要

The invention pertains to the finding that agents capable of inhibiting the binding of cortisol to its receptors can be used in method for preventing antipsychtic-induced weight gain. Mifepristone, a potent specific glucocorticoid receptor antagonist, is combined with an antipsychotic medication to inhibit or reverse antipsychotic symptoms and weight gain associated with the antipsychotic medication.