Association of the HTR2C-759CT polymorphism and antipsychotic-induced weight gain:a meta-analysis

摘要

Background Antipsychotic-induced weight gain(AIWG)is a crucial factor for the medication cessation of patients with schizophrenia.Multiple studies have shown that the functional polymorphism-759 C/T(rs3813929)in the HTR2C promoter region could possibly be correlated with AIWG.Aim To evaluate the genetic association of the HTR2C-759C/T polymorphism and AIWG in patients with schizophrenia with antipsychotic drugs(APDs)administration.Methods Eligible studies were identified by searching the following databases:PubMed,Embase,Web of Science,China Nation Knowledge Infrastructure(CNKI),VIP,Wanfang Data,Chinese Biomedical Literature Database(CBM)and the Airiti Library.The quality of studies was evaluated based on the Newcastle-Ottawa Scale.The pooled OR and 95%Cl were calculated for the dominant(CT/TT/T vs CC/C)mode,and subgroup analyses were performed based on ethnicity,antipsychotic medication and gender;ail statistical analyses were performed using the statistical software STATA V.12.0.Result A total of 17 studies with 3170 patients with schizophrenia were included in our meta-analysis.The result of the meta-analysis has shown that the association between the-759 C/T polymorphism and AIWG is statistically significant(OR 0.34,95%Cl:0.20 to 0.57,z=4.11,p<0.001).The subgroup analyses revealed significant correlations between the-759 C/T polymorphism and AIWG in the Caucasian population(OR 0.33,95%CI:0.14 to 0.77,z=2.55,p=0.011),the Asian population(OR 0.31,95%Cl:0.18 to 0.52,z=4.46,p<0.001),the patients with APDs administration(CT/JTfJ vs CC/C:OR 0.63,95%Cl:0.40 to 1.00,z=1.97,p=0.049)and the patients with atypical antipsychotic drug administration(CT/TT/T vs CC/C:OR 0.21,95%Cl:0.09 to 0.47,z=3.83,p<0.001).The sensitivity analysis showed that the results were stable.Begg''s test(after correction z=1.07,p=0.287)and Egger''s test(t=-2.41,p=0.029)show that the included articles have no significant publication bias.Conclusion There is a significant genetic association between HTR2C-759C/T and AIWG,and patients with T allele are less likely to have AIWG.