Pharmacokinetic profile and adverse gastric effect of zinc-piroxicam in rats.

Tagliati CA; Kimura E; Nothenberg MS; Santos SR; Oga S

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Pharmacokinetic profile and adverse gastric effect of zinc-piroxicam in rats.

机译：吡罗昔康锌在大鼠体内的药代动力学和胃不良反应。

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Complexation of piroxicam with zinc extends its absorption time in rats. The time of peak concentration value for complexed piroxicam was 5.27 hr compared to only 2.56 hr for the uncomplexed agent. Piroxicam and zinc-piroxicam show similar inhibitory effects on carrageenin-induced paw edema. Zinc-piroxicam is less irritating than piroxicam on the gastric mucosa.

机译：吡罗昔康与锌的络合延长了其在大鼠中的吸收时间。复合吡罗昔康的峰值浓度时间为5.27小时，而未复合试剂仅为2.56小时。吡罗昔康和锌吡罗昔康对角叉菜胶诱发的爪水肿显示相似的抑制作用。吡罗昔康锌对胃黏膜的刺激性低于吡罗昔康。

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来源
《General Pharmacology》 |1999年第1期|共5页
作者
Tagliati CA; Kimura E; Nothenberg MS; Santos SR; Oga S;
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正文语种 eng
中图分类药学;
关键词
Anti-Inflammatory Agents; Non-Steroidal; Anti-Ulcer Agents; Piroxicam; Stomach; 消炎药; 非甾类; 抗溃疡病药; 吡罗昔康; 胃; 6-氨基己酸;

机译：Anti-Inflammatory Agents;Non-Steroidal;Anti-Ulcer Agents;Piroxicam;Stomach;消炎药;非甾类;抗溃疡病药;吡罗昔康;胃;6-氨基己酸;
入库时间 2022-08-18 11:05:12

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Pharmacokinetic profile and adverse gastric effect of zinc-piroxicam in rats.

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