Synthesis of 3'-3'-Linked Pyrimidine Oligonucleotides Containing an Acridine Moiety for Alternate Strand Triple Helix Formation

摘要

Oligonucleotides with a 3'-3' inversion of polarity containing an acridine moiety attached to the nucleotide base flanking the 3'-3' phosphodiester bond,have been ,syn-thesised,characterised and used to form alternate-strand triple helix complexes.These have been investigated by UV melting studies and CD experiments.