Stereoselective total synthesis of polyrhacitides A and B

摘要

Two aliphatic polyketide natural products, polyrhacitides A and B, have been synthesized in a concise and highly stereoselective manner. The synthesis involved an auxiliary-based acetate aldol reaction to generate the initial stereogenic center and an iterative Wittig reaction, intramolecular oxa-Michael addition, and chelation-controlled reduction reaction as the key steps to generate additional stereocenters. One-pot acid-mediated global deprotection and cyclization reactions shape the final bicyclic lactone core.