Directed branched-regioselective hydroformylation of 2-substituted allylic o-DPPB esters

摘要

Branched-regioselective hydroformylation of allylic o-DPPB esters has been accomplished with mono- and disubstituted alkene functions in good to excellent yields and selectivities. Optimized reaction conditions allowed the reaction of even trisubstitued alkenic functions. These reactions occur as a result of a significant rate-accelerating effect exerted by the catalyst-directing o-DPPB group, as exemplified by highly position-, regio-, and diastereoselective hydroformylation of the geranyl and neryl o-DPPB esters. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007).