Abnormal ejaculation associated with tamsulosin in benign prostatic hyperplasia patients

摘要

Benign prostatic hyperplasia (BPH) refers to excessive cellular growth of glandular and stromal elements of prostate.It is one of the most common condition affecting men,with incidence increasing dramatically after the age of 50 years.alpha_1-Adrenoreceptor antagonists have remained the mainstay of pharmacotherapy in patients suffering from moderate-to-severe BPH,due to their rapid onset of action and symptomatic relief of symptoms associated with BPH.Among all of the alpha-blockers,tamsulosin is the first selective alpha_(1A)-adrenoreceptor antagonist approved for clinical use and is the most commonly prescribed drug for the treatment of BPH.Despite an improved tolerability profile over other alpha_1-blockers,tamsulosin still exhibits high incidence abnormal ejaculation,which can affect the quality of life.The current clinical study demonstrates the recovery of abnormal ejaculation following intermittent tamsulosin treatment in BPH patients.