男性高血压患者动态血压节律异常与良性前列腺增生的相关性研究

摘要

目的:探讨男性高血压患者血压节律异常与良性前列腺增生间的相关性.方法:对198例(45~92岁)高血压合并良性前列性增生的患者进行24 h动态血压监测,根据夜间血压下降率分为杓型组(100例)和非杓型组(98例),比较两组患者低密度脂蛋白、糖化血红蛋白、踝臂指数、收缩压、舒张压、前列腺抗原及前列腺体积.结果:非杓型组和杓型组昼间收缩压[(130.2±9.4) mmHg vs(128.6±7.5) mmHg,(1 mmHg=0.133 kPa)]、昼间舒张压[(76.0±6.1) mmHg vs(75.8±5.5) mmHg]无明显差异,但夜间收缩压[(134.8±9.7) mmHg vs (115.6±3.0) mmHg]及夜间舒张压[(78.8±6.5) mmHg vs(67.5±2.7) mmHg]有显著性差异(P＜0.05),非杓型组和杓型组患者前列腺体积有显著性差异[(44.8±11.6) ml vs(35.4±9.9) ml,P＜0.05].结论:血压患者血压节律异常与前列腺增生程度可能存在相关性.%To investigate the correlation between the circadian rhythm abnormality of blood pressure and benign prostatic hyperplasia in male patients with essential hypertension. Methods: One hundred and ninety-eight male hypertensive patients( aged 45 to 92 years ) were included and divided into dipper group ( 100 patients ) and non-dipper group( 98 patients ) according to the rate of decrease in nocturnal blood pressure by ambulatory blood pressure monitoring. LDL-C, GHb, ABI, SBP, DBP, prostatic antigen and prostatic volume were recorded. Results: There were no statistical differences between non- dipper group and dipper group in day systolic blood pressure [ ( 130. 2 ±9. 4 ) mmHg vs( 128. 6 ±7. 5 ) mmHg ] and day diastolic blood pressure [ ( 76. 0 ±6. 1 ) mmHg vs ( 75. 8 ± 5. 5 ) mmHg ]( P > 0. 05 ). Night systolic blood pressure [ ( 134. 8 ± 9. 7 ) mmHg vs( 115.6 ± 3. 0 ) mmHg ] and night diastolic blood pressure [ ( 78. 8 ± 6. 5 ) mmHg vs( 67. 5 ±2.1 ) mmHg ] in non- dipper group were significantly higher than those in dipper group( P <0. 05 ). Prostatic volume in non-dipper group were significantly higher than those in dipper group [ ( 44. 8 ± 11. 6 ) ml vs( 35. 4 ± 9. 9 ) ml ]. Conclusions: The circadian rhythm abnormality of blood pressure in patients with essential hypertension may be associated with the degree of prostaticrnhyperplasia.