Synthesis and biological evaluation of novel 4,5-bis(dialkylaminoalkyl)-substituted acridines as potent telomeric G-quadruplex ligands.

Laronze Cochard M; Kim YM; Brassart B

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Synthesis and biological evaluation of novel 4,5-bis(dialkylaminoalkyl)-substituted acridines as potent telomeric G-quadruplex ligands.

机译：新型4,5-双（二烷基氨基烷基）-取代的cr啶的合成和生物学评估，作为有效的端粒G-四链体配体。

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Several 4,5-bis(dialkylaminoalkyl)-substituted acridines have been prepared starting from acridine and their telomeric G-quadruplex stabilizing properties were evaluated using FRET melting and TRAP (Telomerase Repeat Amplification Protocol Assay) experiments.

机译：从a啶开始已经制备了几种4,5-双（二烷基氨基烷基）-取代的cr啶，并使用FRET熔解和TRAP（端粒酶重复扩增方案测定）实验评估了其端粒G-四链体稳定特性。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2009年第10期|共9页
作者
Laronze Cochard M; Kim YM; Brassart B;
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正文语种 eng
中图分类医药、卫生;劳动卫生;
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机译：新型4,5-双（二烷基氨基烷基）-取代的cr啶的合成和生物学评估，作为有效的端粒G-四链体配体。
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Synthesis and biological evaluation of novel 4,5-bis(dialkylaminoalkyl)-substituted acridines as potent telomeric G-quadruplex ligands.

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