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首页> 外文期刊>European journal of heart failure: journal of the Working Group on Heart Failure of the European Society of Cardiology >A multicentre cohort study of acute heart failure syndromes in Korea: Rationale, design, and interim observations of the Korean Acute Heart Failure (KorAHF) registry
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A multicentre cohort study of acute heart failure syndromes in Korea: Rationale, design, and interim observations of the Korean Acute Heart Failure (KorAHF) registry

机译:韩国急性心力衰竭综合征的多中心队列研究:韩国急性心力衰竭(KorAHF)注册中心的原理,设计和中期观察

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摘要

Aims The Korean Acute Heart Failure registry (KorAHF) aims to evaluate the clinical characteristics, management, hospital course, and long-term outcomes of patients hospitalized for acute heart failure syndrome (AHFS) in Korea. Methods and results This is a prospective observational multicentre cohort study funded by the Korea National Institute of Health. Patients hospitalized for AHFS in 10 tertiary university hospitals across the country have been consecutively enrolled since March 2011. The study is expected to complete the scheduled enrolment of 5000 patients some time in 2014, and follow-up is planned through 2016. As of April 2012, the interim analysis of 2066 consecutive subjects was performed to understand the baseline characteristics of the population. The mean age was 69 ± 14 years; 55% were male; and 50% were de novo heart failure. The mean left ventricular ejection fraction (LVEF) was 40 ± 18%. Ischaemia was both the leading cause (38%) and the most frequent aggravating factor (26%) of AHFS. ACE inhibitors/ARBs and beta-blockers were prescribed at discharge in 65% and 51% of the patients, respectively. In-hospital mortality was 5.2%, and 0.9% of patients received urgent heart transplantation. Low blood pressure and azotaemia were the most important predictors of in-hospital mortality. The post-discharge 30-day and 180-day all-cause mortality were 1.2% and 9.2%, respectively. Conclusions Our analysis reveals that the prognosis of AHFS in Korea is poor and that there are specific features, including lower blood pressures at admission and lower rates of heart failure related to hypertension, compared with other registries. Adherence to current guidelines should be improved.
机译:目的韩国急性心力衰竭登记系统(KorAHF)旨在评估韩国因急性心力衰竭综合征(AHFS)住院的患者的临床特征,管理,住院过程和长期结果。方法和结果这是一项由韩国国立卫生研究院资助的前瞻性观察性多中心队列研究。自2011年3月以来,全国10所三级大学医院的AHFS住院患者已连续入组。该研究预计在2014年某个时候完成5000名患者的预定入组,并计划在2016年之前进行随访。截至2012年4月,对2066名连续受试者进行了中期分析,以了解该人群的基线特征。平均年龄为69±14岁; 55%是男性;和50%的患者是从头开始心力衰竭。左室平均射血分数(LVEF)为40±18%。缺血是AHFS的主要原因(38%)和最频繁的加重因素(26%)。出院时分别对65%和51%的患者开出ACE抑制剂/ ARB和β受体阻滞剂。住院死亡率为5.2%,接受紧急心脏移植的患者为0.9%。血压低和氮质血症是院内死亡率的最重要预测指标。出院后30天和180天的全因死亡率分别为1.2%和9.2%。结论我们的分析表明,韩国AHFS的预后较差,并且具有其他特征,包括与其他注册表相比,入院时的血压更低,与高血压相关的心力衰竭的发生率更低。对现行准则的依从性应得到改善。

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