Development and pharmacological characterization of a model of sleep disruption-induced hypersensitivity in the rat

摘要

BackgroundSleep disturbance is a commonly reported co-morbidity in chronic pain patients, and conversely, disruption of sleep can cause acute and long-lasting hypersensitivity to painful stimuli. The underlying mechanisms of sleep disruption-induced pain hypersensitivity are poorly understood. Confounding factors of previous studies have been the sleep disruption protocols, such as the pedestal over water' or inverted flower pot' methods, that can cause large stress responses and therefore may significantly affect pain outcome measures.