The effects of antimicrobial and antiepileptic treatmenton the outcome of epilepsy associated with centralnervous system (CNS) infections

摘要

Summary:The course and outcome of epilepsy following central nervous system (CNS) infections has been poorly characterized. Likewise, the impact of antimicrobial treatment as well as other preventative and therapeutic interventions on the development of epilepsy following neurological infectious disorders has been insufficiently studied. The CNS infections that can cause epilepsy may be either acute or chronic-recurrent. For most acute infections, for example, viral encephalitis and bacterial meningitis, the effect of specific antimicrobial treatment on the development of epilepsy cannot be studiedin a controlled manner due to logistic and ethical reasons. In the specific case of neurocysticer-cosis (NCC), the risk of seizures in the short term is reduced following either anthelminthic or cor-ticosteroid treatment or both. The effect of anthelminthic treatment on seizure outcome in the long term has not been studied. Finally, treatment with antiepileptic drugs (AEDs) needs to be optimally defined in the case of epilepsy associated with neurological infectious disorders.