Alteraatife Reprogrammlig of M1/M2 Pheiotype of Mouse Peritoneal Macrophages In Vitro with Interferon-gamma and Interleukin-4

摘要

An important role in the development of the immune response is played by macrophages that acquire either anti-inflammatory Ml or anti-inflammatory M2 phenotype depending on their microenvironment. The possibility of targeted reprogramming of the initial M2 macrophage phenotype towards Ml phenotype and vice versa using macrophage reprogramming factors IFN-y and IL-4, respectively, was demonstrated. We showed that macrophages of genetically different mouse strains did not practically differ by their reprogramming capacity. Our findings suggest that macrophage programming not only participates in the triggering of the immune response, but also can ensure plasticity of functional activity during the developing response.