MODIFIED HUMAN INTERLEUKIN-4 RECEPTOR POLYPEPTIDE AND INDUCTION AGENT FOR DIFFERENTIATION OR POLARIZATION INTO M2 MACROPHAGES

摘要

The present invention addresses the problem of providing: a polypeptide that contributes to polarization into M2 macrophages independent of IL-4; and an induction agent for differentiation or polarization into M2 macrophages.　A polypeptide derived from the human interleukin-4 receptor, the polypeptide being the result of modifying the amino acid sequence given by SEQ ID NO:1 by adding, deleting, or substituting one or more amino acids, preferably by substituting the 242nd isoleucine of the amino acid sequence given by SEQ ID NO:1 with asparagine.