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首页> 外文期刊>Bulletin of experimental biology and medicine >Hepatic and Cerebral Energy Production System in Rats with Acute and Chronic Ethanol Intoxication
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Hepatic and Cerebral Energy Production System in Rats with Acute and Chronic Ethanol Intoxication

机译:急性和慢性乙醇中毒大鼠肝和脑能量产生系统

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摘要

We studied the effects of ethanol on the energy production system in the brain and liver in acute and chronic intoxications. Ethanol was found to inhibit mitochondrial respiratory chain in the liver. Acute ethanol intoxication results in uncoupling of oxidative phosphorylation. NAD-dependent respiration prevails in chronic intoxication. In the brain, ethanol exposure induces a compensated low-energy shift with activation of fast mitochondrial metabolic cluster and uncoupling of oxidative phosphorylation.
机译:我们研究了乙醇对急性和慢性中毒患者大脑和肝脏能量产生系统的影响。发现乙醇会抑制肝脏中的线粒体呼吸链。急性乙醇中毒导致氧化磷酸化解偶联。 NAD依赖性呼吸在慢性中毒中盛行。在大脑中,乙醇暴露会引起线粒体代谢快簇的激活和氧化磷酸化的解偶联,从而引起补偿性低能转移。

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