In Vitro Study of Neuroprotective Properties of GK-2, a New Original Nerve Growth Factor Mimetic

摘要

New nerve growth factor (NGF) mimetic GK-2, a substituted dimeric dipeptide, in a concentration of up to 10~(-9) M produced a protective effect on the culture of immortalized mouse hippocampal neurons (line HT-22) after addition of H_2O_2 and glutamate. GK-2 in a concentration of 10~(-8) M protected rat PC-12 pheochromocytoma cells from the neurotoxin MPTP. The neuroprotective effect of this peptide on the model of oxidative stress was also observed in the primary culture of embryonic rat hippocampal neurons.