The present invention relates generally to novel proteins that bind to the intracellular domains of p55 and p75 TNF-Rs and FAS-R, which modulate the functions of p55 and p75 TNF-Rs and FAS-R and the DNA sequences coding for them . The present invention relates to a novel water-soluble oligomeric TNF-Rs, oligomeric FAS-Rs, and oligomeric receptors having a mixture of TNF-Rs and FAS-R. Furthermore, the present invention relates to the manufacture and use of all of the above.
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