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首页> 外文期刊>Inflammation >Effects of Salvia miltiorrhizae on ICAM-1, TLR4, NF-kappaB and Bax proteins expression in multiple organs of rats with severe acute pancreatitis or obstructive jaundice.
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Effects of Salvia miltiorrhizae on ICAM-1, TLR4, NF-kappaB and Bax proteins expression in multiple organs of rats with severe acute pancreatitis or obstructive jaundice.

机译：丹参对重症急性胰腺炎或梗阻性黄疸大鼠多器官ICAM-1，TLR4，NF-κB和Bax蛋白表达的影响。

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摘要

To observe the protective effects of Salvia miltiorrhizae injection on multiple organs of rats with SAP or OJ. Two hundred eighty-eight rats were used for SAP-associated experiments and OJ-associated experiments. The rats were randomly divided into sham-operated, model control and treated group. According to the different time points after operation, the SAP rats in each group were subdivided into 3, 6 and 12 h groups while the OJ rats were divided into 7, 14, 21 and 28 days groups. The mortality rates, pathological changes and ICAM-1 (only in lung), TLR4 (only in liver), Bax and NF-kappaB proteins expression in multiple organs (liver, kidney, lung, intestinal mucosa, spleen, thymus and lymph nodes) were observed, respectively. The mortality rates of treated groups decreased in both SAP and OJ experiments. Compared to model control group, the pathological changes can be seen in treated groups including; (1) the pathological changes of multiple organs in SAP and OJ experiments were improved, the pathological severity scores of kidney (at 6 h), intestinal mucosa (at 12 h), spleen (at 6 and 12 h), thymus (at 3 and 6 h) and lymph nodes (at 3 and 6 h) in SAP experiment and of liver (on 21 and 28 days), lung (21 days), intestinal mucosa (on 21 and 28 days) and spleen (on 21 and 28 days) in OJ experiment significantly declined (P < 0.05 or P < 0.01); (2) the positive rate of Bax protein in pancreas (at 3 h) and liver (on 6 and 12 h) in SAP experiment and in liver (on 28 days), kidney (on 21 days), and thymus (on 28 days) in OJ experiment were significantly lower (P < 0.05 or P < 0.01); (3) the positive rate of NF-kappaB in liver (at 12 h) and kidney (at 6 h) in SAP experiment and in liver (on 21 days), kidney (on 28 days), intestinal mucosa (on 28 days) and thymus (on 14 days) in OJ experiment significantly decreased (P < 0.05). (4) the positive rate of ICAM-1 in lungs (at 12 h) in SAP experiment was significantly less (P < 0.05). Salvia miltiorrhizae injection can protect multiple organs of SAP or OJ rats and inhibit the expression of ICAM-1, TLR4, NF-kappaB and regulate Bax proteins. Salvia miltiorrhizae may relieve the inflammation response and enhance the immunity function of SAP and OJ rats.
机译：观察丹参注射液对SAP或OJ大鼠多器官的保护作用。 288只大鼠用于SAP相关实验和OJ相关实验。将大鼠随机分为假手术组，模型对照组和治疗组。根据手术后的不同时间点，将每组SAP大鼠分为3、6、12h组，将OJ大鼠分为7、14、21、28d组。多个器官（肝，肾，肺，肠粘膜，脾脏，胸腺和淋巴结）的死亡率，病理变化和ICAM-1（仅在肺部），TLR4（仅在肝部），Bax和NF-κB蛋白表达分别观察。在SAP和OJ实验中，治疗组的死亡率均降低。与模型对照组相比，在治疗组中可以看到病理变化，包括： （1）改善了SAP和OJ实验中多个器官的病理变化，肾脏（6 h），肠粘膜（12 h），脾（6和12 h），胸腺（3）的病理严重程度评分SAP实验中以及肝脏（21天和28天），肺部（21天），肠粘膜（21天和28天）和脾脏（21天和28天）的第6天和第6小时）以及淋巴结（第3天和第6小时）天数在OJ实验中显着下降（P <0.05或P <0.01）; （2）SAP实验中胰腺（3 h）和肝脏（6和12 h）以及肝脏（28天），肾脏（21天）和胸腺（28天）中Bax蛋白的阳性率）在OJ实验中显着降低（P <0.05或P <0.01）; （3）SAP实验中肝脏（12 h）和肾脏（6 h）以及肝脏（21天），肾脏（28天），肠粘膜（28天）中NF-κB的阳性率OJ实验中的胸腺和胸腺（第14天）显着降低（P <0.05）。 （4）SAP实验中（12 h）肺ICAM-1阳性率显着降低（P <0.05）。丹参注射液可以保护SAP或OJ大鼠的多个器官，并抑制ICAM-1，TLR4，NF-κB的表达并调节Bax蛋白。丹参可以减轻炎症反应并增强SAP和OJ大鼠的免疫功能。

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