Beta blocker therapy modifies circadian rhythm acute myocardial infarction.

摘要

Some studies about the onset time of AMI revealed that the peak incidence of pain onset signaling the occurrence of AMI ranged from 08:00 to 11:00 h in presumably diurnally active persons [1,2]. A recent study published by our group showed a morning incidence peak as well [3]. Otherwise the use of beta blockers could be caused by an attenuation or complete removal of the peaks of incidence of myocardial ischemia and AMI [4,5]. When cardio selective beta blocker agents were used, no peaks of incidence were found [6]. The objective of this study is to evaluate, by means of a new method of analysis [7], the presence of circadian variation in the time of onset of AMI in subgroups of patients receiving beta-adrenergic blockade agents.Patients with diagnosis of AMI at ICU discharge in 119 Spanish hospitals, according to WHO criteria, were collected from the ARIAM database. Among the whole group of 14,952 AMI, we selected a subgroup of 2055 patients who were taking beta-blocker agents. The selected study variable was the time of onset of symptoms.