Diamino propionic acid compounds derived from cyclic and Acyclic, heterocilicos and Pharmaceutical compositions useful for blocking the activity ICAMUseful in the treatment of injury caused by reperfusion after acute myocardial infarction.

摘要

Compounds of the formula: in which R1 is a group of formula, in which R1, R2, a, B, u, V, W, X, y, Z,K and N has the meaning that is present in the specifications are useful for the treatment of rheumatoid arthritis, psoriasis, Crohn's disease, multiple sclerosis,Ulcerative colitis, atherosclerosis, restenosis, pancreatitis, Transplant rejection,Delayed graft function and Diseases of ischemia reperfusion injury, including acute myocardial infarction and Stroke.Compounds, Pharmaceutical compositions and intermediaries pro drugs.