Exacerbation of thrombocytopenia in a pregnant woman with thrombocytopenia-absent radius syndrome.

摘要

Thrombocytopenia-absent radius (TAR) syndrome is a rare congenital disease characterized by thrombocytopenia and bilateral absence of the radius [1]. Management of pregnancy in women with TAR syndrome may be difficult and only 6 cases have been reported previously [1-3]. A 35-year-old primigravida at 20 weeks of pregnancy was referred to the Department of Obstetrics at the Centre Hospitalier Regional et Universitaire (CHRU), Lille, France, with a decreased platelet count of 45 000 per mm~3. She had no" history of hereditary hemostatic disorders, recent drug therapy, or infection. There was no reported asthenia, fever, purpura, epistaxis, or gingival bleeding. The liver and spleen were not palpable and there was no adenopathy. Thrombocytopenia associated with bone abnormalities in both arms had been diagnosed during childhood; however, a diagnosis of TAR syndrome had not been established owing to normal findings from a bone marrow examination.