Efficacy and safety of long-term ezetimibe/simvastatin treatment in patients with familial hypercholesterolemia.

摘要

Avellone et al.1 describe the beneficial actions of combination therapy with ezetimibe and simvastatin in both primary and secondary prevention of atherosclerosis in patients with familial hypercholesterolemia. Some additional comments may be of interest.Regarding carotid intima media thickness (cIMT), we draw attention to the greater decrease in high sensitivity C-reactive protein levels with combination therapy (ezetimibe + simvastatin) in the ENHANCE trial.2 This fall was progressive over 2 years, significant (P<0.01) and in broad agreement with the findings of Avellone et al.1 The significant decrease in cIMT after aggressive low density lipoprotein cholesterol (LDL-C) lowering with a statin + ezetimibe reported by Avellone et al.l is also supported by another trial.